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Search Results for " monocarboxylate transporter "

13

Compounds

Cat No. Product Name Synonyms Targets
T1768 7ACC2 Mitochondrial Metabolism , Monocarboxylate transporter
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.
T3210 AZD3965 AZD 3965,AZD-3965 Monocarboxylate transporter
AZD3965 (AZD-3965) is a selective inhibitor of monocarboxylate transporter 1 (MCT1).
T5208 BAY-8002 BAY8002,BAY 8002 Monocarboxylate transporter
BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively).
T14316 AR-C155858 Monocarboxylate transporter
AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).
TN2252 Syrosingopine Dopamine Receptor
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
T7460 α-Cyano-4-hydroxycinnamic acid α-Cyano-4-hydroxycinnamic acid(α-CHCA) Monocarboxylate transporter
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
T5845 7ACC1 DEAC,Coumarin D 1421,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421 Monocarboxylate transporter
7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistan...
T67727 MCT1-IN-3 Monocarboxylate transporter
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) sho...
T26221 MCT1-IN-2 SR13800,SR-13800,SR 13800
SR13800 is a monocarboxylate transporter 1 (MCT1) inhibitor with cell-permeable.
T37822 AR-C 141990 hydrochloride
Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs card...
T37824 MCT4-IN-1 MCT4-IN-1
MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate ...
T70903 KRH102053
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 an...
T68511 KRH102140
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH10214...
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